In particular, the pancreas and the stomach are the most avid base (HCO 3 -) and acid (H +) secretors, respectively. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.ĭigestive processes along the gastrointestinal tract are aided by acidic and basic secretions by a number of epithelia. MT was the recipient of Erasmus exchange program stipend and AG was supported by the FP7 Marie Curie Initial Training Network "IonTraC". stipend from FNU Department of Biology and the Lundbeck Foundation. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: The project was supported by The Danish Council for Independent Research | Natural Sciences (FNU grant number 0602-01527B and 4002-00162), the Novo Nordisk Foundation (grant number 10723001001) and the Lundbeck Foundation (grant number R173-2014-1462). Received: DecemAccepted: ApPublished: May 18, 2015Ĭopyright: © 2015 Wang et al.
PLoS ONE 10(5):Īcademic Editor: Pavel Strnad, RWTH Aachen, GERMANY Furthermore, it seems relevant to re-evaluate whether PPIs should be used in treatment therapies where pancreatic functions are already compromised.Ĭitation: Wang J, Barbuskaite D, Tozzi M, Giannuzzo A, Sørensen CE, Novak I (2015) Proton Pump Inhibitors Inhibit Pancreatic Secretion: Role of Gastric and Non-Gastric H +/K +-ATPases. We propose that proton transport is driving secretion, and that in addition it may provide a protective pH buffer zone and K + recirculation. In conclusion, this study calls for a revision of the basic model for HCO 3 - secretion.
In addition to HCO 3 -, pancreas also secretes K +.
Furthermore, in rats treated with PPIs, pancreatic secretion was inhibited but concentrations of major ions in secretion follow similar excretory curves in control and PPI treated animals. In Capan-1 cells, PPIs inhibited recovery of intracellular pH from acidosis. Pumps have similar localizations in duct cell monolayers (Capan-1) and human pancreas, and notably the gastric pumps are localized on the luminal membranes. Here we show that the gastric HKα1 and HKβ subunits ( ATP4A ATP4B) and non-gastric HKα2 subunits ( ATP12A) of H +/K +-ATPases are expressed in human pancreatic cells. The aim of the present study was to determine whether H +/K +-ATPases are expressed and functional in human pancreatic ducts and whether proton pump inhibitors (PPIs) have effect on those. This alkaline secretion, formed in pancreatic ducts, can be achieved by transporting HCO 3 - from serosa to mucosa or by moving H + in the opposite direction. The mechanism by which pancreas secretes high HCO 3 - has not been fully resolved.